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Serum proline iminopeptidase and (where possible) urinary hydroxyproline were determined in 214 subjects: normal subjects, subjects with chronic kidney disease, subjects with chronic liver disease, subjects with osteitis deformans, subjects with rheumatoid arthritis, and subjects with osteoporosis. The values of the two parameters fully corresponded. It is suggested, therefore, that proline iminopeptidase can be determined instead of hydroxyproline in cases where a primarily destructive bone disease in present.
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