Biomaterial Database

Serum levels of alpha 1-antitrypsin and Pi types in children with bronchiolitis. 1980

I Fidalgo, and M García-Fuentes, and S Docio, and J Rodríguez-Soriano

Alpha 1-antitrypsin levels were determined at the beginning of the disease and after clinical recovery in a group of 51 infants with bronchiolitis, and the results were compared to those obtained in 24 normal infants and in 15 infants with viral bronchopneumonia. Distribution of Pi types in the patients with bronchiolitis was also compared to that observed in a control population of 170 blood donors of the same ethnic background. Both serum levels of alpha 1-antitrypsin and prevalence of non-M phenotypes were not statistically different from the values found in the control groups, thus not supporting the hypothesis that a deficiency of alpha 1-antitrypsin plays a role in the pathogenesis of bronchiolitis. A non explained finding was the lack of elevation of serum level of alpha 1-antitrypsin during the acute phase of the bronchiolitis process, a fact present in the group of patients with bronchopneumonia.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D001990	Bronchiolitis, Viral	An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.	Bronchiolitides, Viral,Viral Bronchiolitides,Viral Bronchiolitis
D001996	Bronchopneumonia	Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.	Bronchial Pneumonia,Bronchial Pneumonias,Bronchopneumonias,Pneumonia, Bronchial,Pneumonias, Bronchial
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000515	alpha 1-Antitrypsin	Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.	Trypsin Inhibitor, alpha 1-Antitrypsin,alpha 1-Protease Inhibitor,alpha 1-Proteinase Inhibitor,A1PI,Prolastin,Serpin A1,Zemaira,alpha 1 Antiprotease,alpha 1-Antiproteinase,1-Antiproteinase, alpha,Antiprotease, alpha 1,Inhibitor, alpha 1-Protease,Inhibitor, alpha 1-Proteinase,Trypsin Inhibitor, alpha 1 Antitrypsin,alpha 1 Antiproteinase,alpha 1 Antitrypsin,alpha 1 Protease Inhibitor,alpha 1 Proteinase Inhibitor
D019896	alpha 1-Antitrypsin Deficiency	Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.	Deficiencies, alpha 1-Antitrypsin,Deficiency, alpha 1-Antitrypsin,alpha 1 Antitrypsin Deficiency,alpha 1-Antitrypsin Deficiencies