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Measurements of corneal thickness, endothelial cell size, endothelial permeability to fluorescein, and intraocular pressure were made in two groups of human subjects: 21 persons with cornea guttata (early Fuchs dystrophy without epithelial edema) and 17 persons age- and sex-matched but with normal corneas. Statistically significant differences were found between the two groups in all four measured variables. The two groups did not differ with respect to the variability in endothelial cell sizes. There were statistically significant positive correlations between endothelial permeability to fluorescein, endothelial cell size, and corneal thickness. The endothelial pump rate was calculated for each group, and the difference was not statistically significant. Our results suggest that the earliest defect in Fuchs' dystrophy is solely a breakdown in barrier function and thus increased permeability, resulting in a thicker cornea.
R R Burns, and
W M Bourne, and
R F Brubaker
January 1980,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
R R Burns, and
W M Bourne, and
R F Brubaker
February 1999,
The British journal of ophthalmology,
R R Burns, and
W M Bourne, and
R F Brubaker
October 2002,
Cornea,
R R Burns, and
W M Bourne, and
R F Brubaker
April 2002,
Cornea,
R R Burns, and
W M Bourne, and
R F Brubaker
August 1968,
Southern medical journal,
R R Burns, and
W M Bourne, and
R F Brubaker
February 1991,
Klinische Monatsblatter fur Augenheilkunde,
R R Burns, and
W M Bourne, and
R F Brubaker
January 1974,
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
R R Burns, and
W M Bourne, and
R F Brubaker
January 2002,
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft,
R R Burns, and
W M Bourne, and
R F Brubaker
August 2020,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
R R Burns, and
W M Bourne, and
R F Brubaker
July 1959,
American journal of ophthalmology,
