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The comparative effects of normothermic intermittent ischemic arrest (IIA) and cardioplegia (C) on left ventricular (LV) performance were assessed by gated cardiac blood pool imaging in 57 patients undergoing aortocoronary bypass surgery. In 34 patients, IIA was employed; 23 patients received C. Patients were studied preoperatively, sequentially in the immediate postoperative period at 30-minute intervals, and at 1 week after the operation, C and IIA groups did not differ in mean (+/- SEM) age, anginal class, number of diseased vessels, previous myocardial infarction, or preoperative ejection fraction (EF)(50 +/- 3% vs 50 +/- 2% [p = ns]). Aortic cross clamp time was greater with C than IIA (50 +/- 5 minutes vs 28 +/- 3 minutes [p = 0.001]). During the six sequential postoperative studies, transient LV dysfunction (greater than or equal to 7% decrease in absolute EF) was observed in 10 patients receiving C and in 16 patients receiving IIA. By time of discharge, 24 of 26 patients had returned to preoperative EF. Mean EF at discharge in the cardioplegia group did not differ compared to preoperative EF; in the IIA group, EF increased compared to preoperative EF (50 +/- 2% vs 55 +/- 2% [p < 0.01]). These data suggest that in patients with normal preoperative LV performance both C and IIA afford satisfactory myocardial preservation during aortocoronary bypass surgery.
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
May 1971,
The New England journal of medicine,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
June 1980,
Archives des maladies du coeur et des vaisseaux,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
June 1982,
Circulation,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
May 1987,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
January 1979,
Scandinavian journal of thoracic and cardiovascular surgery,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
October 1981,
British medical journal (Clinical research ed.),
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
August 1981,
British medical journal (Clinical research ed.),
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
November 1983,
Kaku igaku. The Japanese journal of nuclear medicine,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
June 1979,
The American journal of cardiology,
L A Reduto, and
G M Lawrie, and
J W Reid, and
H H Whissenand, and
G P Noon, and
D Kanon, and
M E DeBakey, and
R R Miller
July 1979,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
