-transparent.png){kind=logo}
The efficacy of pancreatin in vivo was determined in 14 patients with advanced pancreatic insufficiency using a peroral test with 2 g of chymotrypsin substrate, 4-(N-acetyl-L-tyrosyl)aminobenzoic acid, the Lundh test meal and 1000 ml tea. Chymotrypsin hydrolysis was quantified by 4-aminobenzoic acid excreted in 6-hr or 8-hr urine samples. After a control test without pancreatin, one or two tablets of Panpur (Nordmark-700 mg of pancreatin and 50 mg of bile per tablet) were applied simultaneously with the Lundh meal on repeated examinations. The urinary excretion of 4-aminobenzoic acid was restored to normal values in 5 subjects during both sampling periods. With this method, stimulated and substituted chymotrypsin is measured at the same time. The conditions of the tests, both with and without pancreatin replacement, are fully comparable and thus the significance of factors modifying the activity of enzymic components in the digestive tube is limited. The method appears appropriate for the institution of an effect pancreatin therapy and its control in vivo.
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
September 1983,
Vnitrni lekarstvi,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
January 1988,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
March 1982,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
October 1979,
Biochemical medicine,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
March 1985,
Annales de pediatrie,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
January 1989,
Research in veterinary science,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
March 1979,
Zeitschrift fur Gastroenterologie,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
January 1977,
Gastroenterologia Japonica,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
April 1973,
Archives of biochemistry and biophysics,
P Fric, and
F Malis, and
E Kasafírek, and
J Slabý
October 1977,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
