-transparent.png){kind=logo}
Rifampin prophylaxis (20 mg/kg once daily for four days) was used in close contacts of children with Haemophilus influenzae type b (HIB) disease. Two hours after a dose, the concentration of rifampin in serum and saliva exceeded the minimum bactericidal concentrations of organisms obtained from four of the carriers. In both a randomized prospective and an open study, nasopharyngeal carriage was eradicated in 37 (95%) of 39 contacts. No cases of serious H influenzae disease occurred in four to six months of follow-up. At the dose and treatment schedule used, rifampin was safe and effective for eradication of HIB carriage.
Related Publications
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
November 1987,
The New England journal of medicine,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
January 1982,
Pediatric infectious disease,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
July 1983,
American journal of diseases of children (1960),
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
March 1992,
Antimicrobial agents and chemotherapy,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
July 1980,
Pediatrics,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
June 1987,
The Pediatric infectious disease journal,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
August 1986,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
November 1984,
The Journal of pediatrics,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
March 1981,
The Journal of pediatrics,
F Cox, and
R Trincher, and
J P Rissing, and
M Patton, and
G H McCracken, and
D M Granoff
July 1980,
Pediatrics,
