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12 patients suffering from a low cardiac output syndrome following aorto-coronary bypass-graft surgery were treated with a combined therapy. The left ventricular afterload was decreased by Urapidil, and a low dose positive inotropic agent, dobutamine, was added. The right and left ventricular filling pressures were kept constant by simultaneous volume replacement. Decreasing the mean arterial pressure by Urapidil alone from 122 +/-5 mm Hg to 90 +/-3mm Hg raised the cardiac index from 1.8 1/m2 x min to 2.71 1/m2 x min. By addition od dobutamine 5 mu/kg BW x min the cardiac index was further increased to 3.4 1/m2 x min. The heart-rate was unchanged. The pressure-rate-product was decreased by 25% with Urapidil alone (p 7E 0.01) and was only slightly increased after addition of dobutamine. It is concluded that in the patients studied, reduction of the mechanical load on the heart by Urapidil in combination with positive inotropic stimulation of the myocardium by dobutamine improved cardiac haemodynamics without a significant detrimental effect on the myocardial oxygen balance.
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
January 1978,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
September 1981,
Revista espanola de anestesiologia y reanimacion,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
January 1980,
Giornale italiano di cardiologia,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
March 1980,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
January 1991,
Zeitschrift fur Kardiologie,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
December 1986,
Minerva cardioangiologica,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
August 1981,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
January 1979,
Giornale italiano di cardiologia,
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
February 1985,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
P Schmucker, and
N Franke, and
K van Ackern, and
K Peter, and
E Kreuzer
January 1980,
Giornale italiano di cardiologia,
