BIOMAT Database Logo BIOMAT Database Logo

Research on heterocyclic compounds. X.-Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity. 1981

E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo

Since we had previously observed the considerable anti-inflammatory activity of imidazo[1,2-a]pyrazine 2-acetic acid, we prepared a series of imidazo[1,2-a]pyrazine derivatives, bearing some substituents on the pyrazine ring and a carboxylic, acetic or alpha-methylacetic moiety on the imidazole ring. These new compounds were tested for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.

UI MeSH Term Description Entries
D011719 Pyrazines A heterocyclic aromatic organic compound with the chemical formula C4H4N2. Pyrazine
D000700 Analgesics Compounds capable of relieving pain without the loss of CONSCIOUSNESS. Analgesic,Anodynes,Antinociceptive Agents,Analgesic Agents,Analgesic Drugs,Agents, Analgesic,Agents, Antinociceptive,Drugs, Analgesic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents
D000894 Anti-Inflammatory Agents, Non-Steroidal Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Analgesics, Anti-Inflammatory,Aspirin-Like Agent,Aspirin-Like Agents,NSAID,Non-Steroidal Anti-Inflammatory Agent,Non-Steroidal Anti-Inflammatory Agents,Nonsteroidal Anti-Inflammatory Agent,Anti Inflammatory Agents, Nonsteroidal,Antiinflammatory Agents, Non Steroidal,Antiinflammatory Agents, Nonsteroidal,NSAIDs,Nonsteroidal Anti-Inflammatory Agents,Agent, Aspirin-Like,Agent, Non-Steroidal Anti-Inflammatory,Agent, Nonsteroidal Anti-Inflammatory,Anti-Inflammatory Agent, Non-Steroidal,Anti-Inflammatory Agent, Nonsteroidal,Anti-Inflammatory Analgesics,Aspirin Like Agent,Aspirin Like Agents,Non Steroidal Anti Inflammatory Agent,Non Steroidal Anti Inflammatory Agents,Nonsteroidal Anti Inflammatory Agent,Nonsteroidal Anti Inflammatory Agents,Nonsteroidal Antiinflammatory Agents
D013276 Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). Gastric Ulcer,Gastric Ulcers,Stomach Ulcers,Ulcer, Gastric,Ulcer, Stomach,Ulcers, Gastric,Ulcers, Stomach
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Research on heterocyclic compounds, XXIX. Synthesis and antiinflammatory activity of imidazo[1,2-a]pyrazine derivatives.
June 1992, Farmaco (Societa chimica italiana : 1989),
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Research on heterocyclic compounds. XIV - Imidazothiazole and imidazobenzothiazole derivatives: synthesis and antiinflammatory activity.
August 1983, Il Farmaco; edizione scientifica,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Iodine catalyzed synthesis of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyridine derivatives and their anticancer activity.
December 2023, RSC advances,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
[Synthesis of cypridina luciferin and related compounds. V. On the structure of imidazo[1,2-a]pyrazine derivatives].
April 1970, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells.
January 2016, European journal of medicinal chemistry,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Research on heterocyclic compounds. Phenyl derivatives of fused imidazole systems: antiinflammatory activity.
January 1990, Pharmacological research,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
[Research on nitrogen heterocyclic compounds. X. New method of synthesis of pyrrolo/1,2-a/quinoline and its derivatives].
September 1976, Il Farmaco; edizione scientifica,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Research on heterocyclic compounds. XXV. Phenyl derivatives of fused imidazole systems: antiinflammatory activity.
July 1989, Research communications in chemical pathology and pharmacology,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
December 1995, Arzneimittel-Forschung,
E Abignente, and F Arena, and P De Caprariis, and R Nuzzetti, and E Marmo, and E Lampa, and E Rosatti, and R Ottavo
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors.
February 2023, European journal of medicinal chemistry,
Copied contents to your clipboard!