Biomaterial Database

New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads. 1981

J G Meingassner, and H Nesvadba, and H Mieth

The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.

UI	MeSH Term	Description	Entries
D009593	Nitroimidazoles	IMIDAZOLES having a nitro moiety.	Nitroimidazole
D011799	Quinazolines	A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.	Quinazoline
D002621	Chemistry	A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D004352	Drug Resistance, Microbial	The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).	Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000994	Antitrichomonal Agents	Agents used to treat trichomonas infections.	Antitrichomonal Drugs,Antitrichomonals,Trichomonicides,Agents, Antitrichomonal,Drugs, Antitrichomonal
D014244	Trichomonas	A genus of parasitic flagellate EUKARYOTES distinguished by the presence of four anterior flagella, an undulating membrane, and a trailing flagellum.	Trichomona
D014246	Trichomonas vaginalis	A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.	Trichomonas vaginali,vaginali, Trichomonas
D014247	Trichomonas Vaginitis	Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.	Trichomoniasis, Human,Human Trichomoniases,Human Trichomoniasis,Trichomonas Vaginitides,Trichomoniases, Human,Vaginitides, Trichomonas,Vaginitis, Trichomonas