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During family and population studies in a Finnish isolate (Salla), a variant of alpha 1-antitrypsin, tentatively called PI MSAL was found. On isoelectric focusing this variant was slightly cathodal to M3. With the aid of acid starch gel electrophoresis, differentiation from M3 proved reliable, because the variant was unstable in that system. The variant also showed an increased lability at + 56 degrees C and physiological pH and a decreased stability at pH 4.5 and room temperature compared to the other M subtypes. By genealogical studies it was possible to trace a common ancestor, a settler arriving to the parish around 1680, for the three families where the variant was found.
R R Frants, and
A W Eriksson
June 1977,
Scandinavian journal of clinical and laboratory investigation,
R R Frants, and
A W Eriksson
September 1988,
Human genetics,
R R Frants, and
A W Eriksson
May 1980,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
R R Frants, and
A W Eriksson
May 1982,
The American review of respiratory disease,
R R Frants, and
A W Eriksson
January 1980,
Bulletin europeen de physiopathologie respiratoire,
R R Frants, and
A W Eriksson
January 2000,
Human heredity,
R R Frants, and
A W Eriksson
January 1983,
Human genetics,
R R Frants, and
A W Eriksson
January 1985,
Human genetics,
R R Frants, and
A W Eriksson
January 2018,
Annals of thoracic medicine,
R R Frants, and
A W Eriksson
January 1981,
Human heredity,
