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The ability of levamisole to enhance proliferation of murine lymphocyte preparations stimulated by concanavalin A was examined. Levamisole substantially augmented the proliferation of C57Bl/6 thymic lymphocytes, but had only marginal effects on the proliferation of splenic lymphocytes. The possibility that this difference was related to the degree of cell maturation was examined by peanut agglutinin fractionation of the thymic lymphocytes. Levamisole was found to stimulate proliferation most effectively in the mature fraction. However, since the focus of levamisole activity might be on macrophages, also shown to be present in preparations of splenic and thymic lymphocytes and in both PNA separated fractions, the drug's activity was compared to several macrophage replacements: LAF-IL 1, 2-mercaptoethanol, and added splenic adherent cells. Added plastic adherent cells and 2-mercaptoethanol were effective in augmentation of proliferation of both mature and immature populations whereas LAF-IL 1 like levamisole was most effective on the mature population.
I G Otterness, and
L B Lachman, and
M L Bliven
January 1992,
Archivum immunologiae et therapiae experimentalis,
I G Otterness, and
L B Lachman, and
M L Bliven
January 2001,
JPEN. Journal of parenteral and enteral nutrition,
I G Otterness, and
L B Lachman, and
M L Bliven
July 1983,
Neurology,
I G Otterness, and
L B Lachman, and
M L Bliven
November 1975,
Cellular immunology,
I G Otterness, and
L B Lachman, and
M L Bliven
January 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
I G Otterness, and
L B Lachman, and
M L Bliven
September 1978,
Nihon Kyobu Shikkan Gakkai zasshi,
I G Otterness, and
L B Lachman, and
M L Bliven
November 1979,
Clinical and experimental immunology,
I G Otterness, and
L B Lachman, and
M L Bliven
January 1992,
Immunology,
I G Otterness, and
L B Lachman, and
M L Bliven
January 1989,
Actas urologicas espanolas,
I G Otterness, and
L B Lachman, and
M L Bliven
September 2016,
Endocrine,
