Biomaterial Database

Precursor T cell leukemia--immunological, cytochemical and morphological studies. 1981

T Morita, and R Morita, and S Takagi, and N Shimoyama, and K Nagai

A case of acute lymphoblastic leukemia with a giant splenomegaly in an 8-year-old boy was investigated by immunological, cytochemical and electronmicroscopical techniques. Bone marrow and peripheral blood were largely replaced by large blast cells with a nonconvoluted nucleus. Cytochemically, most of the blast cells showed strong focal acid phosphatase activity. In the surface marker studies, these blast cells formed EAC rosettes but not E rosettes, while they showed positive reactivity with anti-T lymphocyte serum but not with anti-B lymphocyte serum. This membrane phenotype E-, C3R+, T+, B- suggested that leukemic blast cells in this patient presumably originated from precursor T cells.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D006651	Histocytochemistry	Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.	Cytochemistry
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000135	Acid Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	Acid beta-Glycerophosphatase,Acid beta Glycerophosphatase
D013601	T-Lymphocytes	Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.	T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D054218	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.	Leukemia, Lymphoblastic, Acute, T-Cell,Leukemia, Lymphocytic, Acute, T-Cell,Leukemia, T-Cell, Acute,Lymphoblastic Leukemia, Acute, T-Cell,Lymphocytic Leukemia, T-Cell, Acute,T-ALL,T-Cell Leukemia, Acute,T-Lymphocytic Leukemia, Acute,Leukemia, Lymphoblastic, Acute, T Cell,Leukemia, Lymphocytic, Acute T Cell,Lymphoblastic Leukemia, Acute, T Cell,Lymphocytic Leukemia, T Cell, Acute,Precursor T-Cell Lymphoblastic Leukemia,Precursor T-Cell Lymphoblastic Lymphoma,T-Cell Acute Lymphocytic Leukemia,Acute T-Cell Leukemia,Acute T-Cell Leukemias,Acute T-Lymphocytic Leukemia,Acute T-Lymphocytic Leukemias,Leukemia, Acute T-Cell,Leukemia, Acute T-Lymphocytic,Leukemias, Acute T-Cell,Leukemias, Acute T-Lymphocytic,Precursor T Cell Lymphoblastic Leukemia,Precursor T Cell Lymphoblastic Leukemia Lymphoma,Precursor T Cell Lymphoblastic Lymphoma,T Cell Leukemia, Acute,T Lymphocytic Leukemia, Acute,T-Cell Leukemias, Acute,T-Lymphocytic Leukemias, Acute