-transparent.png){kind=logo}
A 53-year old male and his daughter (38 years old) had primary biliary cirrhosis. The daughter had a high titer of antimitochondrial and other autoantibodies. Nine members, including, four living sibs, mother and two of the daughter's healthy offspring have been examined for liver function, the presence of autoimmune antibodies, cell mediated immunity and histocompatibility antigens. The eldest and second sons, mother and sisters of the affected daughter had multiple autoimmune reactions including antismooth-muscle antibodies and decreased peripheral T lymphocyte but liver tests were normal except in the eldest son. Histocompatibility antigens HL-A9 and HL-B5 were present in both patients and the elder son. Thus the findings suggest a similar genetic predisposition to immunologic abnormalities among the family members of the patients with primary biliary cirrhosis.
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
August 1976,
Gastroenterology,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
January 2001,
The American journal of gastroenterology,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
June 1994,
Journal of hepatology,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
September 2010,
Digestive diseases and sciences,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
November 1984,
Gastroenterologie clinique et biologique,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
January 1984,
Sovetskaia meditsina,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
August 1999,
Journal of autoimmunity,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
March 2004,
The Korean journal of hepatology,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
October 1987,
Scottish medical journal,
Y Kato, and
K Suzuki, and
M Kumagai, and
K Nishimura, and
H Miyamori, and
K Kobayashi, and
N Hattori, and
Y Nakanuma
January 2002,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
