Biomaterial Database

Effect of adenosine on oxygen uptake and electrolyte content of frog sartorius muscle. 1981

M Prosdocimi, and C P Bianchi

Adenosine and ATP depressed resting O2 uptake in frog sartorius. This action was blocked by low levels of caffeine and by 8-phenyltheophylline. It was mimicked by a polymer of adenosine. Adenosine also decreased radioactive calcium uptake in muscles. Potassium and magnesium content were increased while sodium and calcium content were decreased by adenosine. Adenosine did not decrease oxygen uptake in muscles from frogs sacrificed in winter months. However, adenosine deaminase, which inactivates adenosine by removing the amino group, increased oxygen uptake, calcium content and lactate release of these muscles. Our results suggest that adenosine reduces resting metabolism, possibly through reducing passive leaks of electrolytes.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D011894	Rana pipiens	A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research.	Frog, Leopard,Leopard Frog,Lithobates pipiens,Frogs, Leopard,Leopard Frogs
D004573	Electrolytes	Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	Electrolyte
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan
D000243	Adenosine Deaminase	An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.	Adenosine Aminohydrolase,Aminohydrolase, Adenosine,Deaminase, Adenosine
D000255	Adenosine Triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.	ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000266	Adenylyl Imidodiphosphate	5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.	Adenyl Imidodiphosphate,gamma-Imino-ATP,AMP-PNP,AMPPNP,ATP(beta,gamma-NH),Adenosine 5'-(beta,gamma-Imino)triphosphate,Adenylimidodiphosphate,Adenylylimidodiphosphate,Mg AMP-PNP,Mg-5'-Adenylylimidodiphosphate,beta,gamma-imido-ATP,gamma-Imido-ATP,AMP-PNP, Mg,Imidodiphosphate, Adenyl,Imidodiphosphate, Adenylyl,Mg 5' Adenylylimidodiphosphate,Mg AMP PNP,beta,gamma imido ATP,gamma Imido ATP,gamma Imino ATP
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia