Biomaterial Database

3-Methyladenine nucleosides: their synthesis, ring opening, and glycosidic bond cleavage. 1980

T Fujii, and T Saito, and T Nakasaka

3-Methyladenosine (Va) and 3-methyl-2'-deoxyadenosine (Vb) have been synthesized in the form of the p-toluenesulfonate salt by methylation of N'-benzyloxy-5-formamido-1-beta-D-ribofuranosylimidazole-4-carboxamidine (IIa) and of N'-benzyloxy-1-(2-deoxy-beta-D-ribofuranosyl)-5-formamidoimidazole-4-carboxamideine (IIb) followed by hydrogenolysis of the N'-benzyloxy group and cyclization. The 3-methyladenine nucleosides thus obtained are very unstable, and their hydrolytic cleavage of the glycosidic bond and ring opening of the adenine ring have been studied.

UI	MeSH Term	Description	Entries
D007202	Indicators and Reagents	Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)	Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D003839	Deoxyadenosines	Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.	Adenine Deoxyribonucleosides,Adenylyldeoxyribonucleosides,Deoxyadenosine Derivatives,Deoxyribonucleosides, Adenine,Derivatives, Deoxyadenosine
D006027	Glycosides	Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)	Glycoside
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan