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Anthracycline antibiotics rubomycin (daunomycin) and carminomycin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium. The strains of Staph. aureus and Fisher mouse ascitic lymphadenosis L-5178/P resistant to rubomycin preserved sensitivity to carminomycin. The resistance of the bacterial and tumor strains to rubomycin was accompanied by a significant decrease in the accumulation of rubomycin in the cells. At the same time carminomycin also effectively accumulated in the cells of Staph. aureus and Fisher ascitic lymphadenosis adapted to rubomycin, the same as in the cells of the parent strains.
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
October 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
July 1979,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
January 1977,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
April 1982,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
October 1982,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
January 1983,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
April 1983,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
October 1978,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
June 1984,
Antibiotiki,
L N Ostanina, and
L A Averbukh, and
V L Karpov, and
Iu V Dudnik, and
V A Liashenko
October 1981,
Antibiotiki,
