[Pathomorphology of acute lymphoblastic leukemia. Gyrification of the nucleus of lymphoblast cells]. 1980

T Pap, and I Retih, and P Kajtár

In 9 children out of 36 with ALL examined post mortem at the Department of Pathology of the Medical University of Pécs in the period 1960--1978 leukaemic infiltrates were not found at all ("total remission"). 7 cases out of the 9 observed during the last 5 years. The remaining 27 cases could be divided into two groups: at 20 children nuclei of the leukaemic cells have shown marked gyrification. Survival of children of this group was 10.8 months. At the remaining 7 children the surface of the cell nuclei appeared to be smooth. The survival in this group was 3.6 months. These data support the hypothesis according to which ALL of the children and T cell malignant lymphomas may be of two types. Those with gyrificated and with non-gyrificated nuclei. The considerable difference in survival of patients with these two types of leukaemia suggests that the morphology of the cell nuclei i.e. "gyrification" or "non-gyrification" of them may be used in estimation of the prognosis.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008297 Male Males
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001757 Blastomeres Undifferentiated cells resulting from cleavage of a fertilized egg (ZYGOTE). Inside the intact ZONA PELLUCIDA, each cleavage yields two blastomeres of about half size of the parent cell. Up to the 8-cell stage, all of the blastomeres are totipotent. The 16-cell MORULA contains outer cells and inner cells. Blastocytes,Blastocyte,Blastomere
D002467 Cell Nucleus Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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