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A benzophenone derivative, 4-butyl-2'-fluorobenzophenone (KC-8973), having anti-inflammatory effects has been studied pharmacologically and toxicologically. On the carrageenin-induced paw edema, KC-8973 had the most potent activity of the tested commercial non-steroidal anti-inflammatory drugs. KC-8973 had a moderate effect on bradykinin-induced capillary permeability and lesser effect on dextran-, egg white- and serotonin-induced paw edemas in rats, respectively. From the detailed studies of prophylactic and therapeutic effects on the adjuvant-induced arthritis in rats, it was demonstrated that KC-8973 has an immuno-suppressive activity in addition to an anti-inflammatory effect. KC-8973 had a local-analgesic and antipyretic effect on the rat paw edema induced by brewer's yeast. KC-8973 caused no undesirable side effect at pharmacologically effective dose in the 1-month sub-acute toxicological study.
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
July 1986,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
January 1985,
Drugs under experimental and clinical research,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
February 1990,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
October 1977,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
November 1986,
Japanese journal of pharmacology,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
January 1979,
Arzneimittel-Forschung,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
August 1986,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
July 1986,
Methods and findings in experimental and clinical pharmacology,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
December 1984,
Agents and actions,
T Matsuo, and
K Amemiya, and
K Saga, and
Y Hamazaki, and
M Tanaka, and
T Kato
August 1975,
Ugeskrift for laeger,
