-transparent.png){kind=logo}
The genetic variation of the enzyme isoniazid-N-acetyltransferase has been studied in man and other species. Homogenates of liver samples of adult LEW rats also acetylate procainamide. The kinetic properties of isoniazid and procainamide acetylation are similar and are consistent with a ping-pong Bi-Bi mechanism. The experimental data support the hypothesis that one acetyltransferase catalyses both procainamide and isoniazid. Furthermore, a simple spectrophotometric assay to determine procainamide acetylation is presented.
Related Publications
E Kattner, and
R Dubbels, and
W Schloot
January 1984,
Drug metabolism and disposition: the biological fate of chemicals,
E Kattner, and
R Dubbels, and
W Schloot
January 1982,
Drug metabolism and disposition: the biological fate of chemicals,
E Kattner, and
R Dubbels, and
W Schloot
January 1978,
The Journal of pharmacology and experimental therapeutics,
E Kattner, and
R Dubbels, and
W Schloot
December 1978,
The Journal of pharmacology and experimental therapeutics,
E Kattner, and
R Dubbels, and
W Schloot
October 1979,
The Journal of pharmacy and pharmacology,
E Kattner, and
R Dubbels, and
W Schloot
December 1998,
Biological & pharmaceutical bulletin,
E Kattner, and
R Dubbels, and
W Schloot
May 1983,
Biochemistry international,
E Kattner, and
R Dubbels, and
W Schloot
June 1969,
Biochimica et biophysica acta,
E Kattner, and
R Dubbels, and
W Schloot
February 1987,
Kokyu to junkan. Respiration & circulation,
E Kattner, and
R Dubbels, and
W Schloot
September 1989,
Journal of cardiovascular pharmacology,
