Biomaterial Database

Effect of x-irradiation on immunocompetency of T-lymphocytes. 1981

C W Song, and J G Rhee, and T Kim, and J H Kersey, and S H Levitt

Effect of x-irradiation on various aspects of cell-mediated immune reactions is studied. The irradiated splenic lymphocytes could transform to blast cells upon stimulation with PHA, but could not divide into small lymphocytes. It was concluded that irradiation at doses higher than 500 rads inhibits the differentiation of lymphocytes to effector cells upon stimulation with antigens. The irradiated immune lymphocytes were able to kill target tumor cells when the cytotoxicity was tested immediately after irradiation with doses as high as 500 rads. The cytotoxicity of immune lymphocytes diminished, however, 7--10 hours after irradiation. The splenic lymphocytes irradiated with doses as high as 200 rads could stimulate allogeneic lymphocytes 2 days after the irradiation. It thus appeared that irradiation cannot immediately abolish the antigenicity of lymphocytes to stimulate allogeneic lymphocytes. The combined effect of irradiation and T-cell-mediated immune reaction to reduce clonogenecity of target tumor cells in vitro is simple additive.

UI	MeSH Term	Description	Entries
D007121	Immunocompetence	The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.	Competence, Immunologic,Immunologic Competence,Immunological Competence,Competence, Immunological
D010835	Phytohemagglutinins	Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.	Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001345	Autoradiography	The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)	Radioautography
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013601	T-Lymphocytes	Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.	T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor