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A description is given of a rat anti-mouse hybridoma antibody, JIId, which reacts with erythrocytes, neutrophils, greater than 90% of thymus cells, and most B cells. JIId does not have detectable activity for mature T cells, pluripotential stem cells, platelets, or cells of the monocyte-macrophage lineage. Although the JIId antigen is present on 90 to 95% of typical small B lymphocytes, pretreatment of spleen cells with JIId plus complement has no effect on secondary IgG antibody responses; by contrast, primary IgM responses and proliferative responses to lipopolysaccharide are substantially reduced. Unlike the precursors of IgG antibody-producing cells (AFC), IgG AFC per se are strongly JIId-positive. Rapid acquisition of the JIId antigen also applied to the early progeny of pluripotential stem cells.
J Bruce, and
F W Symington, and
T J McKearn, and
J Sprent
August 1979,
Proceedings of the National Academy of Sciences of the United States of America,
J Bruce, and
F W Symington, and
T J McKearn, and
J Sprent
July 1980,
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J Bruce, and
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T J McKearn, and
J Sprent
January 1979,
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J Bruce, and
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March 1994,
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J Sprent
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J Bruce, and
F W Symington, and
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J Sprent
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J Bruce, and
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J Sprent
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J Bruce, and
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J Sprent
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J Bruce, and
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J Sprent
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J Bruce, and
F W Symington, and
T J McKearn, and
J Sprent
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