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Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse. A dose-dependent tremor was produced by all routes of administration of harmine. Although oxotremorine tremor was markedly suppressed by atropine, harmine tremor was unaffected by cholinergic drugs, remarkably inhibited by dopaminergic drugs, antidepressants and diazepam, mildly diminished by p-chlorophenylalanine, markedly augmented by 5-hydroxytryptophan and mildly increased by alpha-methyl-p-tyrosine. These findings suggest that a catecholaminergic (particularly dopaminergic) and serotonergic system imbalance plays an important role in the manifestation of harmine tremor. In view of these characteristics, harmine tremor may be useful as an effective experimental model for the evaluation of antiparkinsonism drugs, along with oxotremorine tremor because of the different mechanism of occurrence. In addition, harmine tremor appears to be useful in characterizing the properties of antidepressant drugs.
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
January 1994,
Alcohol and alcoholism (Oxford, Oxfordshire),
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
June 1974,
European journal of pharmacology,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
July 1992,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
September 1987,
Neuropharmacology,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
November 1978,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
August 2009,
European journal of pharmacology,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
January 1955,
International archives of allergy and applied immunology,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
May 1958,
Minerva anestesiologica,
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
March 1996,
Alcohol and alcoholism (Oxford, Oxfordshire),
K Kawanishi, and
Y Hashimoto, and
M Fujiwara, and
Y Kataoka, and
S Ueki
March 1991,
Synapse (New York, N.Y.),
