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The lymphocytes from 20 cases of mild rheumatoid arthritis have been explored thanks to a monoclonal antibody found in a murine hybridoma of specificity I-E/Ck, "cross-reacting" with the human molecules HLA-DR+. A slight increase in the lymphocyte subpopulation T-DR+ is found, representing 25.15% versus 18.5% of the lymphocytes T isolated by rosettes in the normal subject. These cells correspond to a subpopulation of T lymphocytes whose immunologic function remains to be defined.
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