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Venous blood samples were collected prospectively in ten menstrual cycles where conception occurred, and for several weeks thereafter, and the circulating concentrations of pregnancy specific beta 1 glycoprotein (SP1) and human chorionic gonadotrophin (HCG) determined using specific radioimmunoassays. The data were converted to logarithms and pooled and pooled using the day of the LH peak as zero time. The concentration profiles so obtained were remarkable similar and showed a rapid exponential increase in concentration during the very early stage of pregnancy. The doubling times were 2.4 days and 2.3 days for SP1 and HCG respectively and both proteins were initially secreted in approximately equivalent concentrations. However, some 30 days following the LH peak, the concentration profiles began to diverge, with SP1 levels continuing to rise whilst HCG concentrations showed the characteristic plateau at 8 and 10 weeks of gestation.
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
August 1981,
The Australian & New Zealand journal of obstetrics & gynaecology,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
January 1984,
Gynecologic and obstetric investigation,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
November 1981,
The Journal of reproductive medicine,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
January 1985,
Placenta,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
August 1980,
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
July 1999,
Human reproduction (Oxford, England),
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
June 1988,
British journal of obstetrics and gynaecology,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
May 1989,
Clinica chimica acta; international journal of clinical chemistry,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
January 1989,
Histochemistry,
E A Lenton, and
J G Grudzinskas, and
Y B Gordon, and
T Chard, and
I D Cooke
January 1979,
Acta obstetricia et gynecologica Scandinavica,
