Biomaterial Database

Micellar solubilization of cetaben sodium in surfactant and lipid solutions. 1981

S L Chow, and B E Sims

Cetaben sodium solubilities were evaluated by micellar solubilization in various surfactants and lipid solvents. At pH 8, the relationship between cetaben sodium solubility and surfactant concentration delineated apparent saturable kinetics; at pH 4.9, the relationship between the two parameters was linear. In the presence of 0.5% sodium taurocholate and polysorbate 80, cetaben sodium solubility increased as the medium pH was increased; however, in the presence of 0.5% poloxamer 188, cetaben sodium solubility revealed a hyperbola when the pH was changed from 4.9 to 8.0. Cetaben sodium solubility was enhanced greatly by mixed physiological surfactants, full-strength caprylic-capric monodiglycerides or monodiglycerides, when compared to a single surfactant system. Cetaben sodium solubility is influenced by pH, surfactant type, surfactant concentration, lipid solvent type, and the simultaneous presence of surfactants or phospholipids.

UI	MeSH Term	Description	Entries
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008823	Micelles	Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.	Micelle
D010129	4-Aminobenzoic Acid	An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.	PABA,p-Aminobenzoic Acid,para-Aminobenzoic Acid,4-Aminobenzoic Acid, Potassium Salt,Aminobenzoic Acid (USP),Epit Vit,Epitelplast,Hachemina,Magnesium para-Aminobenzoate,Pabasan,Paraminan,Paraminol,Potaba,Potassium 4-Aminobenzoate,Potassium Aminobenzoate,4 Aminobenzoic Acid,4 Aminobenzoic Acid, Potassium Salt,4-Aminobenzoate, Potassium,Aminobenzoate, Potassium,Potassium 4 Aminobenzoate,p Aminobenzoic Acid,para Aminobenzoic Acid,para-Aminobenzoate, Magnesium
D003102	Colloids	Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.	Hydrocolloids,Colloid,Hydrocolloid
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D013501	Surface-Active Agents	Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.	Surface Active Agent,Surface-Active Agent,Surfactant,Surfactants,Tenside,Amphiphilic Agents,Surface Active Agents,Tensides,Active Agent, Surface,Active Agents, Surface,Agent, Surface Active,Agent, Surface-Active,Agents, Amphiphilic,Agents, Surface Active,Agents, Surface-Active
D062365	Aminobenzoates	Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.	Aminobenzoic Acids,Acids, Aminobenzoic
D062366	para-Aminobenzoates	Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.	4-Aminobenzoate,p-Aminobenzoate,para-Aminobenzoate,4-Aminobenzoates,p-Aminobenzoates,4 Aminobenzoate,4 Aminobenzoates,p Aminobenzoate,p Aminobenzoates,para Aminobenzoate,para Aminobenzoates