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The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
P Gallagher, and
B M Vose, and
M Moore, and
P F Schofield
January 1978,
Oncology,
P Gallagher, and
B M Vose, and
M Moore, and
P F Schofield
February 1984,
Gut,
P Gallagher, and
B M Vose, and
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P F Schofield
January 1984,
Gastroenterology,
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P F Schofield
October 1977,
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P Gallagher, and
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Clinical immunology and immunopathology,
P Gallagher, and
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P F Schofield
April 1975,
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P Gallagher, and
B M Vose, and
M Moore, and
P F Schofield
October 1984,
Gut,
P Gallagher, and
B M Vose, and
M Moore, and
P F Schofield
October 1983,
Clinical and experimental immunology,
