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Isoproterenol (IPR) induces myocardial lesions in R. pipiens adapted to +25 degrees C, but not to +8 degrees C. The spontaneous healing of these lesions in the form of ventricular wall aneurysms occurs during the first three weeks after IPR, and the ultrastructure of the myocardial cells in fully restored from the fourth week after IPR. Leukocytes, adhering to the lacunar endothelium and including phagocytic vacuoles, appear 8-15 days after IPR. Severely altered heart muscle cells then contain myelin figures or a pyknotic nucleus. In the acute stage of the IPR-lesions, heart muscle preparations from the ventricular wall show a very lowered resistance towards cyanide anoxia as judged from the isometric force decay. During the seven weeks of observation after IPR the resistance to cyanide anoxia is continuously improved almost to normal values. Thus restoration of structure and function occurs in parallel.
A Carlsten, and
L E Ericson, and
O Poupa
August 1973,
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A Carlsten, and
L E Ericson, and
O Poupa
December 1970,
American heart journal,
A Carlsten, and
L E Ericson, and
O Poupa
September 1972,
Bollettino chimico farmaceutico,
A Carlsten, and
L E Ericson, and
O Poupa
May 1970,
Canadian journal of physiology and pharmacology,
A Carlsten, and
L E Ericson, and
O Poupa
January 1969,
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A Carlsten, and
L E Ericson, and
O Poupa
January 1975,
Recent advances in studies on cardiac structure and metabolism,
A Carlsten, and
L E Ericson, and
O Poupa
January 1983,
Comparative biochemistry and physiology. A, Comparative physiology,
A Carlsten, and
L E Ericson, and
O Poupa
January 1985,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
A Carlsten, and
L E Ericson, and
O Poupa
November 1980,
Acta pharmacologica et toxicologica,
A Carlsten, and
L E Ericson, and
O Poupa
June 1972,
La Vie medicale au Canada francais,
