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The effect of riboflavin on nitrite treated erythrocytes from normal subjects and patients with hereditary methaemoglobinaemia due to the deficiency of NADH-cytochrome b5 reductase was studied in the presence of glucose, 2-deoxy-D-glucose or lactate. When glucose or 2-deoxy-D-glucose was used as a substrate for these erythrocytes, the rate of methaemoglobin reduction in these cells was accelerated more than two-fold in the presence of riboflavin. The acceleration was dependent on the concentration of riboflavin and was suppressed by the addition of atebrin. The stimulative effect of riboflavin was, however, not observed when lactate was used in place of glucose or 2-deoxy-D-glucose. On the basis of these results, the acceleration of methaemoglobin reduction by riboflavin was considered to be due to the activation of NADPH-flavin reductase (Yubisui et al, 1977) in erythrocytes by the reagent. The availability of riboflavin for patients with methaemoglobinaemia due to the deficiency of NADH-cytochrome b5 reductase and for those with toxic methaemoglobinaemia is discussed in relation to methaemoglobin reducing systems in erythrocytes.
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
May 1980,
The Biochemical journal,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
July 2005,
The international journal of biochemistry & cell biology,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
May 1977,
Experientia,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
March 1993,
Biochemical pharmacology,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
August 1962,
The Biochemical journal,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
March 1971,
The Indian journal of medical research,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
January 1977,
Comparative biochemistry and physiology. B, Comparative biochemistry,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
January 1951,
The Australian journal of experimental biology and medical science,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
October 1970,
Blood,
T Matsuki, and
T Yubisui, and
A Tomoda, and
Y Yoneyama, and
M Takeshita, and
M Hirano, and
K Kobayashi, and
Y Tani
January 1973,
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