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A group of 22 patients with acute purulent exacerbations of chronic bronchitis were treated with 1 g erythromycin ethyl succinate granules twice daily orally for 10 days. Half the patients were given bromhexine additionally and the other half received placebo instead. Serum and sputum erythromycin concentrations were measured microbiologically at intervals after the first dose. The clinical results in both treated groups were rather poor, with many patients becoming infected again immediately after the chemotherapy. Blood and sputum concentrations of erythromycin did not greatly differ in the two patient groups. The sputum concentration of erythromycin was often higher than the blood concentration at the same time. The MIC's of erythromycin (in particular, those for the Haemophilus influenzae strains) were often higher than the drug concentrations attained in the sputum.
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
March 1978,
European journal of clinical pharmacology,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
September 1971,
Arztliche Forschung,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
June 1980,
Thorax,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
January 1974,
British journal of diseases of the chest,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
October 1981,
Thorax,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
October 1970,
British medical journal,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
June 2012,
The European respiratory journal,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
January 1967,
Indian journal of medical sciences,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
December 1999,
Respiratory medicine,
F P Maesen, and
B I Davies, and
J Brouwers, and
G Rubingh
December 1966,
Physiotherapy,
