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In a rat model, the relationship between the activity of PKA in human PPFs, the changes in arterial BK concentration, and the changes in blood pressure on infusion of PPF was investigated. The rat was chosen as a model because it is reported to be one of the few animals sensitive to human PKA. However, hypotensive reactions after infusion of human PKA-containing PPF were observed only in the presence of a bradykinin-potentiating peptide (BPP9a). A correlation was found between the PKA content of the rapidly infused PPF, the BK generation in the rat, and the fall in arterial blood pressure. In control experiments, infusions of BK provoKed a similar fall in blood pressure at corresponding BK levels. After neutralization of the PKA activity in the PPF with C1-esterase inhibitor, neither a rise in BK level nor a fall in blood pressure was observed on infusion. We conclude therefore that the hypotensive reactions were caused by PKA-mediated generation of BK.
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1980,
Developments in biological standardization,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
July 1978,
The New England journal of medicine,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
March 1982,
The Annals of thoracic surgery,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1980,
The Annals of thoracic surgery,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1989,
Doklady Akademii nauk SSSR,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
July 1982,
Thrombosis research,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
August 1982,
The Journal of laboratory and clinical medicine,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1979,
Developments in biological standardization,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1981,
Thrombosis research,
W K Bleeker, and
R F Van Rosevelt, and
J G Ufkes, and
J A Loos, and
J A Van Mourik, and
J C Bakker
January 1981,
Revista clinica espanola,
