BIOMAT Database Logo BIOMAT Database Logo

HLA-DR4 antigen and IgM rheumatoid factors. 1982

M V Queirós, and M R Sancho, and J M Caetano

To investigate the possible relation between the DR4 antigen and IgM rheumatoid factors (RF). 80 patients with rheumatoid arthritis were tested for 7 HLA-DR antigens and 38 HLA-A, B, C antigens, and compared with 66 normal controls. The DR4 antigen prevalence was 48.7% in the patients and 12.1% in the controls (p less than 0.001). Studying the relationship between the HLA-DR4 antigen and IgM, the genetic marker was present in 89.7% of 51 seropositive patients and in 39% of 29 seronegatives (p less than 0.00001). On the other hand we discovered a positive association between HLA-DR3 and antinuclear antibodies (p less than 0.01). These results suggest the existence of immune response genes in the major histocompatibility complex of humans.

UI MeSH Term Description Entries
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000936 Antigen-Antibody Complex The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. Immune Complex,Antigen-Antibody Complexes,Immune Complexes,Antigen Antibody Complex,Antigen Antibody Complexes,Complex, Antigen-Antibody,Complex, Immune,Complexes, Antigen-Antibody,Complexes, Immune
D000949 Histocompatibility Antigens Class II Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen. Antigens, Immune Response,Class II Antigens,Class II Histocompatibility Antigen,Class II Major Histocompatibility Antigen,Ia Antigens,Ia-Like Antigen,Ia-Like Antigens,Immune Response Antigens,Immune-Associated Antigens,Immune-Response-Associated Antigens,MHC Class II Molecule,MHC II Peptide,Class II Antigen,Class II Histocompatibility Antigens,Class II MHC Proteins,Class II Major Histocompatibility Antigens,Class II Major Histocompatibility Molecules,I-A Antigen,I-A-Antigen,IA Antigen,MHC Class II Molecules,MHC II Peptides,MHC-II Molecules,Antigen, Class II,Antigen, I-A,Antigen, IA,Antigen, Ia-Like,Antigens, Class II,Antigens, Ia,Antigens, Ia-Like,Antigens, Immune-Associated,Antigens, Immune-Response-Associated,I A Antigen,II Peptide, MHC,Ia Like Antigen,Ia Like Antigens,Immune Associated Antigens,Immune Response Associated Antigens,MHC II Molecules,Molecules, MHC-II,Peptide, MHC II,Peptides, MHC II

Related Publications

M V Queirós, and M R Sancho, and J M Caetano
[Rheumatoid arthritis and HLA-DR4, antigen].
April 1988, Zhonghua nei ke za zhi,
M V Queirós, and M R Sancho, and J M Caetano
Rheumatoid factors and HLA-DR4 in RA.
April 1985, The Journal of rheumatology,
M V Queirós, and M R Sancho, and J M Caetano
The association between rheumatoid arthritis and the HLA antigen DR4.
June 1983, Annals of the rheumatic diseases,
M V Queirós, and M R Sancho, and J M Caetano
Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production.
April 1983, Clinical immunology and immunopathology,
M V Queirós, and M R Sancho, and J M Caetano
Seronegative rheumatoid arthritis and HLA-DR4.
February 1994, The Journal of rheumatology,
M V Queirós, and M R Sancho, and J M Caetano
HLA-DR4 antigen and IgA nephropathy.
November 1980, Tissue antigens,
M V Queirós, and M R Sancho, and J M Caetano
How useful are tests for rheumatoid factors, antiperinuclear factors, antikeratin antibody, and the HLA DR4 antigen for the diagnosis of rheumatoid arthritis?
January 1995, Revue du rhumatisme (English ed.),
M V Queirós, and M R Sancho, and J M Caetano
HLA-DR4 and pulmonary dysfunction in rheumatoid arthritis.
April 1987, The American journal of medicine,
M V Queirós, and M R Sancho, and J M Caetano
HLA-DR4 restriction, molecular mimicry and rheumatoid arthritis.
February 1997, Immunology today,
M V Queirós, and M R Sancho, and J M Caetano
HLA DR4 and rheumatoid arthritis in Japanese people.
June 1981, Annals of the rheumatic diseases,
Copied contents to your clipboard!