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Histomorphometric studies of bone biopsies were performed on 12 hemodialyzed patients before and after six months of treatment with 25-(OH) and 1 alpha-(OH) vitamin D3. Patients could be classified into three groups according to bone resorption: Group I with normal bone resorption; Group II with elevated initial bone resorption unresponsive to vitamin D treatment; group III with elevated initial bone resorption sensitive to vitamin D treatment. None of the patients had histological signs of osteomalacia. In Group I, plasma concentrations of 24,25-(OH)2D and the ratio of 24,25-(OH)2D to 25-(OH) D remained in the normal range throughout the study; in Group II these parameters were subnormal initially and did not increase above normal except in one case; in Group III, plasma concentrations of 24,25-(OH)2D were high before or at the beginning of vitamin D administration and normal at the time of the second biopsy and wide variations were observed in the ratio of 24,25-(OH)2D to 25-(OH)D. No difference was found between these last two groups with regard to the cumulative dose of vitamin D derivatives administered or the changes in plasma PTH, CT, calcium and phosphate. These observations suggest a specific regulation of plasma 24,25-(OH)2D concentrations in hemodialyzed patients and a possible link (independent of circulating PTH, CT, or phosphate) between this regulation and healing of bone resorption. However, no correlation was found between plasma 24,25-(OH)2D and either one of the simultaneously measured biochemical or histological parameters.
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
January 2001,
Steroids,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
September 1981,
Kidney international,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
October 1983,
The Journal of clinical endocrinology and metabolism,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
September 1979,
American journal of obstetrics and gynecology,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
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C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
September 2019,
Clinical chemistry and laboratory medicine,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
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P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
October 1981,
Clinical chemistry,
G Lambrey, and
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P Meunier, and
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A Fournier
February 1991,
The Journal of clinical endocrinology and metabolism,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
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P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
September 2016,
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
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J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
February 1979,
The Journal of laboratory and clinical medicine,
G Lambrey, and
T M N'Guyen, and
M Garabedian, and
J L Sebert, and
J F de Fremont, and
P Marie, and
C Caillens, and
J Gueris, and
P Meunier, and
S Balsan, and
A Fournier
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