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Vitamin D metabolites were measured in 21 patients with hypophosphatemic osteomalacia of juvenile onset. In eight patients who had not received any antirachitic treatment, serum 25-hydroxyvitamin D(25-OH-D) and 1,25-dihydroxyvitamin D (1,25-[OH]2D) values were normal, whereas serum 24,25-dihydroxyvitamin D (24,25-[OH]2D) values were lower than in normal subjects. In 13 patients who were receiving ergocalciferol and oral elemental phosphorus, serum 25-OH-D and 24,25-(OH)2D concentrations were elevated and serum 1,25-(OH)2D values were low. The findings in untreated patients supported the hypothesis that vitamin D metabolism is abnormal in hypophosphatemic rickets/osteomalacia. The reduction of serum 1,25-(OH)2D levels with ergocalciferol and phosphate therapy gives further support to a therapeutic role for 1,25-(OH)2D in this disorder.
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
January 1980,
Contributions to nephrology,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
October 1971,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
October 1984,
Boletin medico del Hospital Infantil de Mexico,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
January 1977,
Ugeskrift for laeger,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
January 1998,
Ryoikibetsu shokogun shirizu,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
January 1987,
Revista de pediatrie, obstetrica si ginecologie. Pediatria,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
February 1972,
The Journal of pediatrics,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
November 1976,
Pediatric clinics of North America,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
November 1972,
The Orthopedic clinics of North America,
R S Mason, and
P G Rohl, and
D Lissner, and
S Posen
January 1976,
Revista de pediatrie, obstetrica si ginecologie. Pediatria,
