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A total of 15 patients with advanced neoplastic disease, 13 with different solid tumors, one with lymphoma, and one with acute lymphocytic leukemia, underwent treatment consisting of continuous infusion of methotrexate (2 g/sq m/day) with concomitant thymidine (8 g/sq m/day) and leucovorin (1 mg/sq m/day). The dose of methotrexate was increased progressively by lengthening the methotrexate infusion from 2 to 7 days. After cessation of methotrexate infusion, thymidine and leucovorin were continued until the plasma level of methotrexate decreased to 2 X 10(-8) M. Toxicity was mucositis (23 of 27 evaluable courses), leukopenia (15 of 26 evaluable courses), thrombocytopenia (10 of 26 evaluable courses), renal and hepatic toxicity and diarrhea. Plateau levels of plasma methotrexate or methotrexate plasma half-life did not correlate with toxicity.
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
August 1978,
Cancer nursing,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
February 1979,
Cancer treatment reports,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
January 1992,
International journal of radiation oncology, biology, physics,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
January 1991,
The Journal of rheumatology,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
June 2001,
Cancer chemotherapy and pharmacology,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
March 1983,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
April 1980,
Onkologie,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
September 1991,
Cancer,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
November 1996,
Cancer,
S Bruno, and
G Grindey, and
S Zakrzewski, and
R Priore, and
J Kinahan, and
H Moayeri, and
E Ledesma, and
A Mittelman, and
P Creaven
January 1991,
Cancer chemotherapy and pharmacology,
