BIOMAT Database Logo BIOMAT Database Logo

Comparative biological activities of highly potent active-site analogues of alpha-melanotropin. 1982

T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider

UI MeSH Term Description Entries
D008116 Lizards Reptiles within the order Squamata that generally possess limbs, moveable EYELIDS, and EXTERNAL EAR openings, although there are some species which lack one or more of these structures. Chameleons,Geckos,Chameleon,Gecko,Lizard
D008545 Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D009074 Melanocyte-Stimulating Hormones Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS. MSH,Melanocyte Stimulating Hormone,Melanocyte-Stimulating Hormone,Melanophore Stimulating Hormone,Melanotropin,MSH (Melanocyte-Stimulating Hormones),Melanophore-Stimulating Hormone,Hormone, Melanocyte Stimulating,Hormone, Melanocyte-Stimulating,Hormone, Melanophore Stimulating,Melanocyte Stimulating Hormones,Stimulating Hormone, Melanocyte,Stimulating Hormone, Melanophore
D011894 Rana pipiens A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research. Frog, Leopard,Leopard Frog,Lithobates pipiens,Frogs, Leopard,Leopard Frogs
D002627 Chemistry, Physical The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes. Physical Chemistry,Chemistries, Physical,Physical Chemistries
D000262 Adenylyl Cyclases Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP. Adenyl Cyclase,Adenylate Cyclase,3',5'-cyclic AMP Synthetase,Adenylyl Cyclase,3',5' cyclic AMP Synthetase,AMP Synthetase, 3',5'-cyclic,Cyclase, Adenyl,Cyclase, Adenylate,Cyclase, Adenylyl,Cyclases, Adenylyl,Synthetase, 3',5'-cyclic AMP
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D012880 Skin Pigmentation Coloration of the skin. Skin Color,Skin Tone,Color, Skin,Colors, Skin,Pigmentation, Skin,Pigmentations, Skin,Skin Colors,Skin Pigmentations,Skin Tones,Tone, Skin,Tones, Skin

Related Publications

T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Comparative biological activities of potent analogues of alpha-melanotropin. Effect of nonaromatic and para substituted aromatic amino acids at position 7.
June 1986, International journal of peptide and protein research,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Biological activities of ACTH-analogues varied in the active site.
March 1977, Acta endocrinologica,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Synthesis and biological activity of highly active alpha-aza analogues of luliberin.
October 1978, Journal of medicinal chemistry,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10.
January 1989, Journal of medicinal chemistry,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
December 1989, Journal of medicinal chemistry,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6.
April 2002, Biochemical and biophysical research communications,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Specific antibodies against alpha-melanotropin for radioimmunoassay. Parallelism between the immunochemical cross-reactions of melanotropin structural analogues and their biological activity.
May 1977, European journal of biochemistry,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Synthesis and biological activities of fatty acid conjugates of a cyclic lactam alpha-melanotropin.
January 1992, Journal of medicinal chemistry,
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Design, synthesis, and biological properties of highly potent epothilone B analogues.
August 2003, Angewandte Chemie (International ed. in English),
T K Sawyer, and V J Hruby, and B C Wilkes, and M T Draelos, and M E Hadley, and M Bergsneider
Design, synthesis, and biological properties of highly potent tubulysin D analogues.
January 2007, Chemistry (Weinheim an der Bergstrasse, Germany),
Copied contents to your clipboard!