BIOMAT Database Logo BIOMAT Database Logo

Specific cytotoxic activity of normal T-lymphocytes coated with multivalent hybrid antibody. 1982

M Laky, and G Mota, and V Gheţie

Mouse lymphoid cells treated with multivalent hybrid antibody consisting of rabbit IgG anti-T antibody and rabbit IgG anti-chicken red blood cell antibody formed rosettes and killed specifically chicken red blood cells. The attachment and killing of chicken red blood cells is due to multivalent hybrid antibody which is able to link with one antibody specificity (anti-T) the T-lymphocytes and with the other one the chicken red blood cell surface antigen(s). Some indirect results seem to suggest natural killer cells as a candidate for the multivalent hybrid antibody-induced cytolytic effects. Multivalent hybrid antibody can be a useful alternative to mitogen for assaying specifically the cytotoxic potential of various cell populations pre-existing in normal organisms and requiring only a link to the target cells to reveal their killing ability.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008297 Male Males
D008806 Mice, Inbred AKR An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. Mice, AKR,Mouse, AKR,Mouse, Inbred AKR,AKR Mice,AKR Mice, Inbred,AKR Mouse,AKR Mouse, Inbred,Inbred AKR Mice,Inbred AKR Mouse
D003602 Cytotoxicity, Immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D000918 Antibody Specificity The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site. Antibody Specificities,Specificities, Antibody,Specificity, Antibody
D000936 Antigen-Antibody Complex The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. Immune Complex,Antigen-Antibody Complexes,Immune Complexes,Antigen Antibody Complex,Antigen Antibody Complexes,Complex, Antigen-Antibody,Complex, Immune,Complexes, Antigen-Antibody,Complexes, Immune

Related Publications

M Laky, and G Mota, and V Gheţie
Generation of Aspergillus-specific T lymphocytes with cytotoxic activity.
January 2004, The Egyptian journal of immunology,
M Laky, and G Mota, and V Gheţie
Specific inhibition of CD4+ T lymphocytes by a hybrid antibody.
March 1998, Nature biotechnology,
M Laky, and G Mota, and V Gheţie
Multivalent hybrid antibody.
March 1980, Molecular immunology,
M Laky, and G Mota, and V Gheţie
Tumour-reactive cytotoxic T-lymphocytes specific for normal cellular proteins.
May 1997, Biochemical Society transactions,
M Laky, and G Mota, and V Gheţie
Target cell lysis by cytotoxic T lymphocytes redirected by antibody-coated polystyrene beads.
September 1989, Journal of immunology (Baltimore, Md. : 1950),
M Laky, and G Mota, and V Gheţie
HIV-specific cytotoxic T lymphocytes.
January 1989, Research in immunology,
M Laky, and G Mota, and V Gheţie
Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2.
February 1981, Nature,
M Laky, and G Mota, and V Gheţie
Isolation of HIV-1-specific cytotoxic T lymphocytes using human leukocyte antigen-coated beads.
October 1999, AIDS (London, England),
M Laky, and G Mota, and V Gheţie
HIV-gag-specific cytotoxic T lymphocytes.
January 1989, Research in immunology,
M Laky, and G Mota, and V Gheţie
Allogeneic tumor-specific cytotoxic T lymphocytes.
January 1992, Cancer immunology, immunotherapy : CII,
Copied contents to your clipboard!