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[Relative polyribosome content in peripheral blood lymphocytes and lymphoid organs in the human]. 1982

E O Morozova, and M N Blinov

Using ultracentrifugation, relative contents of polysomes and free ribosomes were calculated in human PHA activated or non-activated peripheral lymphocytes, peripheral chronic lymphocytic leukemia lymphocytes, and in spleen and adenoid lymphocytes in the total fraction as well as in that separated into T and B lymphocytes. The polysome amount in B cells was higher (47%) that in T cells (30%). The polysome and free ribosome correlation in lymphocytes of lymphoid organs and in peripheral blood was different to be presumably dependent on population composition of lymphocytes and on their maturation and proliferation. 20-25% of ribosomes in peripheral lymphocytes are found in polysomes; in PHA stimulated leukemic and spleen lymphocytes they reach 50-70%, and in adenoid lymphocytes, -40%. The participation of polysomes, rather than monosomes, in protein synthesis in lymphocytes has been shown irrespective of the polysome--free ribosome correlation in these.

UI MeSH Term Description Entries
D006965 Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. Hyperplasias
D007223 Infant A child between 1 and 23 months of age. Infants
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008221 Lymphoid Tissue Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS. Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D011132 Polyribosomes A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) Polysomes,Polyribosome,Polysome
D011696 Purpura, Thrombocytopenic Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms. Purpura, Thrombopenic,Purpuras, Thrombocytopenic,Purpuras, Thrombopenic,Thrombocytopenic Purpura,Thrombocytopenic Purpuras,Thrombopenic Purpura,Thrombopenic Purpuras
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000234 Adenoids A collection of lymphoid nodules on the posterior wall and roof of the NASOPHARYNX. Pharyngeal Tonsils,Tonsil, Pharyngeal,Pharyngeal Tonsil,Adenoid,Tonsils, Pharyngeal

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