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Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls; p less than 0.005, corrected P greater than 0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls; P less than 0.005, corrected P less than 0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P less than 0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR/-negative patients (0.46 vs 0.18; P less than 0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype of HLA-DR5 antigen.
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1977,
The Journal of rheumatology,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1977,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
September 1985,
Ryumachi. [Rheumatism],
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1979,
Lakartidningen,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1981,
Immunological communications,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
February 1983,
The Journal of rheumatology,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
May 1983,
The Journal of laboratory and clinical medicine,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1975,
Arthritis and rheumatism,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
February 1981,
The Journal of laboratory and clinical medicine,
C J Lynch, and
G Singh, and
T L Whiteside, and
G P Rodnan, and
T A Medsger, and
B S Rabin
January 1978,
Acta medica Academiae Scientiarum Hungaricae,
