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The T suppressive factor (TsF) released from a T15-idiotype-positive phosphocholine (PCho)-specific T hybridoma, F18-3-4, which was formed by fusion between BALB/c T cells and BW5147 thymoma, was immunochemically characterized. TsF inhibited the in vitro induction of both IgE and IgG1 antibody responses of 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH)-primed spleen cells in the presence of PCho-KLH-DNP. TsF had the ability to bind to PCho determinants and possessed T15 idiotype determinants as well as Iad products. However, we were unable to detect either the rearrangement of the T15 VH gene or the presence of T15 VH gene transcripts in hybridomas by DNA and RNA blot hybridization analyses with the T15 VH DNA probe.
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
January 1981,
International archives of allergy and applied immunology,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
March 1982,
Journal of immunology (Baltimore, Md. : 1950),
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
January 1982,
Journal of immunology (Baltimore, Md. : 1950),
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
January 1987,
Monographs in allergy,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
August 1983,
The Journal of experimental medicine,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
November 1984,
European journal of immunology,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
June 1987,
Journal of immunology (Baltimore, Md. : 1950),
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
September 1975,
Scandinavian journal of immunology,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
August 1982,
Surgery,
K Nakanishi, and
K Sugimura, and
Y Yaoita, and
K Maeda, and
S Kashiwamura, and
T Honjo, and
T Kishimoto
November 1998,
Molecular and cellular biology,
