Biomaterial Database

The effect of ATP on survival in intestinal ischemia shock, hemorrhagic shock, and endotoxin shock in rats. 1982

C Van der Meer, and P M Snijders, and P W Valkenburg

Mg-ATP 72 mumole/kg was injected into anesthetized rats subjected to intestinal ischemia shock (SAO), hemorrhagic shock (HS), and endotoxin shock (ES), shock models in which all untreated animals died. Administration of Mg-ATP in no instance improved survival rate. In SAO, Mg-ATP given intra-arterially (IA) or intraperitoneally (IP) before the period of ischemia significantly reduced the survival time, and when given IA after the period of ischemia caused no significant change in survival time. In HS survival time was not significantly altered if Mg-ATP was given IA before or after the period of hypotension, but if given IP before bleeding survival time was significantly prolonged. Marked hemodynamic effects of Mg-ATP were observed resulting in reduction of the maximum bleeding volume and in an earlier spontaneous reuptake of the shed blood. In ES survival time was not affected if the Mg-ATP was given before the endotoxin, but survival time was significantly decreased if Mg-ATP was given before as well as after the endotoxin. It is concluded that any beneficial effect of ATP is probably small, whereas the occurrence of adverse effects cannot be neglected.

UI	MeSH Term	Description	Entries
D007269	Injections, Intra-Arterial	Delivery of drugs into an artery.	Injections, Intraarterial,Intra-Arterial Injections,Intraarterial Injections,Injection, Intra-Arterial,Injection, Intraarterial,Injections, Intra Arterial,Intra Arterial Injections,Intra-Arterial Injection,Intraarterial Injection
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D007422	Intestines	The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.	Intestine
D007511	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	Ischemias
D005260	Female		Females
D000255	Adenosine Triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.	ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012771	Shock, Hemorrhagic	Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.	Hemorrhagic Shock
D012772	Shock, Septic	Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.	Endotoxin Shock,Septic Shock,Shock, Endotoxic,Shock, Toxic,Toxic Shock,Toxic Shock Syndrome,Endotoxin Shocks,Shock Syndrome, Toxic,Shock, Endotoxin,Shocks, Endotoxin,Toxic Shock Syndromes
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus