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Methylmercury (MeHg) is an extremely potent neurotoxin about 25% of which is degraded in vivo to inorganic mercury. Piperonyl butoxide (PB) is a widely used pesticidal synergist which inhibits many mammalian detoxification reactions. In a preliminary experiment with the high doses of PB and MeHg, PB induced a 12% decrease in mean survival time and a 20% decrease in mean latency time to neurotoxicity. The weight loss in PB-MeHg group was far greater than the control MeHg group. In a dose response experiment, mean survival times in rats fed 40 ppm MeHg-C1 were 5.75, 5.3, and 5.0 weeks at 0, 0.5, and 1% PB, respectively. By the ninth week 25% of rats fed 20 ppm MeHg-C1 showed neurotoxicity and 63% of the 0.5% PB fed showed neurotoxicity with some mortality. In experiments at 20 ppm MeHg-C1 both PB fed groups weighted considerably less than corresponding controls.
M A Friedman, and
L R Eaton
February 1988,
Biochemical pharmacology,
M A Friedman, and
L R Eaton
May 1974,
Nature,
M A Friedman, and
L R Eaton
January 1983,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
M A Friedman, and
L R Eaton
October 1993,
Toxicology,
M A Friedman, and
L R Eaton
September 2022,
Reproductive toxicology (Elmsford, N.Y.),
M A Friedman, and
L R Eaton
January 1992,
Toxicology,
M A Friedman, and
L R Eaton
April 1967,
Nature,
M A Friedman, and
L R Eaton
January 1995,
Toxicology and industrial health,
M A Friedman, and
L R Eaton
November 1970,
Toxicology and applied pharmacology,
M A Friedman, and
L R Eaton
April 1994,
Toxicology letters,
