Biomaterial Database

[Effect of rimazolium (Probon) on biotransformation reactions in the rat]. 1982

H H Bühring, and W Klinger

Rimazolium inhibits ethylmorphine-N-demethylation and ethoxycoumarin-O-deethylation by rat liver homogenate when added in vitro in dependence on reaction differently, but marked effects are observed with high concentrations only (10(-3) mol). Both reactions are inhibited after administration of a high sedative dose (180 mg/kg) by 30-40%, after a non-sedative dose no inhibition could be observed. After a 4 d treatment both reactions were not influenced when investigated 24 h after the last administration, the induction by phenobarbital is inhibited in case of ethylmorphine-N-demethylation by rimazolium, but increased in case of ethoxycoumarin-O-deethylation.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D010105	Oxygenases	Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.	Oxygenase
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D011744	Pyrimidinones	Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	Pyrimidinone,Pyrimidone,Pyrimidones
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005037	Ethylmorphine-N-Demethylase	A drug-metabolizing enzyme of the hepatic microsomal oxidase system which catalyzes the oxidation of the N-methyl group of ethylmorphine with the formation of formaldehyde.	Ethylmorphine N Demethylase,Demethylase, Ethylmorphine N,N Demethylase, Ethylmorphine
D006591	Hexobarbital	A barbiturate that is effective as a hypnotic and sedative.	Evipan,Hexenal,Hexobarbitone,Sodium Hexobarbital,Hexobarbital, Sodium
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D015660	7-Alkoxycoumarin O-Dealkylase	A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.	7-Ethoxycoumarin O-Dealkylase,7-Ethoxycoumarin O-Deethylase,7-Ethoxycoumarin Dealkylase,7-Ethoxycoumarin Hydroxylase,7-Ethoxycoumarin Monooxygenase,7-Ethoxycoumarin O-De-Ethylase,7-Propoxycoumarin O-Depropylase,Cytochrome P-450-Dependent O-Dealkylase,Ethoxycoumarin Deethylase,Ethoxycoumarin O-Deethylase,7 Alkoxycoumarin O Dealkylase,7 Ethoxycoumarin Dealkylase,7 Ethoxycoumarin Hydroxylase,7 Ethoxycoumarin Monooxygenase,7 Ethoxycoumarin O De Ethylase,7 Ethoxycoumarin O Dealkylase,7 Ethoxycoumarin O Deethylase,7 Propoxycoumarin O Depropylase,Cytochrome P 450 Dependent O Dealkylase,Dealkylase, 7-Ethoxycoumarin,Deethylase, Ethoxycoumarin,Ethoxycoumarin O Deethylase,Hydroxylase, 7-Ethoxycoumarin,Monooxygenase, 7-Ethoxycoumarin,O-Deethylase, 7-Ethoxycoumarin,O-Depropylase, 7-Propoxycoumarin,P-450-Dependent O-Dealkylase, Cytochrome