Clinical significance of the detection of circulating immune complexes in lupus nephritis. 1982

R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli

32 patients (22 biopsed) with lupus nephritis (LN) were observed for circulating immune complexes (IC). Solid phase C1q (SPC1q) and polyethylene glycol (PEG) precipitation tests were used. The patients were studied during the clinical follow-up in different phases of disease activity. Comparative studies between each histological class of LN and corresponding forms of idiopathic glomerulonephritis (IGN) were made: no significant differences were found between either mesangial LN and stalk mesangial IGN, or between focal proliferative LN an focal proliferative IGN. However, a significant difference was found for SPC1q data between diffuse proliferative LN and mesangiocapillary IGN, and between membranous LN and membranous IGN. LN, with an acute nephritic syndrome and hypocomplementemia, displayed SPC1q data significantly above the levels of IC found in IGN with similar clinical features. IC serum data would seem an important element for the diagnosis and the clinical management of patients affected by LN.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009393 Nephritis Inflammation of any part of the KIDNEY. Nephritides
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D011233 Precipitin Tests Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate. Precipitin Test,Test, Precipitin,Tests, Precipitin
D003166 Complement Activating Enzymes Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. They are enzymes in the various COMPLEMENT ACTIVATION pathways. Activating Enzymes, Complement,Enzymes, Complement Activating
D005260 Female Females
D005921 Glomerulonephritis Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY. Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
October 1991, The American journal of medicine,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
September 1979, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
January 1978, Nephron,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
June 1988, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
January 2022, Frontiers in immunology,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
January 1977, La Ricerca in clinica e in laboratorio,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
January 1982, The American journal of the medical sciences,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
October 1982, ZFA. Zeitschrift fur Allgemeinmedizin,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
January 1980, Progress in clinical immunology,
R Coppo, and G M Bosticardo, and B Basolo, and M Messina, and G Mazzucco, and P Stratta, and F Quarello, and S Alloatti, and G Piccoli
May 1978, The New England journal of medicine,
Copied contents to your clipboard!