-transparent.png){kind=logo}
1. The effects of intravenous morphine on the firing of single sensory neurones in the thalamus of the anaesthetized rat are described. 2. Low doses (0.38 to 2.00 mg/kg) of morphine depressed the excitation of nucleus lateralis neurones produced by natural noxious stimuli but were without effect on spontaneous activity. The excitation of some of these neurones by iontophoretically applied acetylcholine or glutamate was also depressed by morphine. These effects were reversed by intravenous (0.25 to 1.17 mg/kg) but not iontophoretically applied (50 to 200 nA) naloxone. 3. Similar or higher doses of morphine (0.58 to 5.07 mg/kg) did not prevent the excitation of ventrobasal thalamic neurones by non-noxious stimuli. 4. The possibility of a direct action of intravenous morphine in the thalamus is discussed.
R G Hill, and
C M Pepper
July 1978,
Neuropharmacology,
R G Hill, and
C M Pepper
October 1992,
Japanese journal of pharmacology,
R G Hill, and
C M Pepper
February 1977,
Neuropharmacology,
R G Hill, and
C M Pepper
February 1986,
Pain,
R G Hill, and
C M Pepper
January 1991,
Pain,
R G Hill, and
C M Pepper
June 2006,
Neuroscience letters,
R G Hill, and
C M Pepper
February 1977,
Brain research,
R G Hill, and
C M Pepper
April 1983,
Pain,
R G Hill, and
C M Pepper
May 1977,
The Journal of physiology,
R G Hill, and
C M Pepper
January 1998,
Fundamental & clinical pharmacology,
