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The effects of the four main forms of gastrin (component I, gastrin-34, gastrin-17, and gastrin-14) on insulin, glucagon, and exocrine secretion were measured on the isolated perfused porcine pancreas. All gastrins were studied in concentrations ranging from 10(-11) to 10(-8) M. Depending on the glucose concentration in the perfusate, all four gastrins increased insulin or glucagon secretion in a dose-dependent manner in concentrations above 10(-10) M. These concentrations are slightly above the arterial concentrations in normal pig and man, but they correspond to gastrin concentrations measured in patients with achlorhydria and gastrinomas. The exocrine secretion was stimulated by all gastrins in a dose-dependent manner. The lowest concentrations that stimulated flow rate significantly were within the physiologic range, 10(-11) and 10(-10) M. All gastrins induced maximal flow rate at a concentration of 10(-9) M. The sulfated form of gastrin-17 had the greatest efficacy. The results indicate that all gastrins may influence the exocrine secretion under normal conditions and the endocrine secretion in diseases with endogenous hypergastrinemia.
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
October 1978,
The American journal of physiology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
October 1978,
The American journal of physiology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
March 1981,
Acta physiologica Scandinavica,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
July 1981,
The American journal of physiology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
March 1978,
Surgery, gynecology & obstetrics,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
January 1994,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
January 1991,
The Japanese journal of physiology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
January 1975,
Toxicology and applied pharmacology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
January 1980,
The Japanese journal of physiology,
S L Jensen, and
J F Rehfeld, and
J J Holst, and
J Fahrenkrug, and
O V Nielsen, and
O B Schaffalitzky de Muckadell
January 1993,
Pancreas,
