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Influenza infection in renal transplant recipients may cause either morbidity and mortality or acute allograft rejection; thus, routine annual influenza vaccination should be considered. We have studied the humoral and cellular immune responses to influenza virus antigens before and after trivalent vaccine administration in 13 patients and 16 control subjects. The patients, nine of whom were either on alternate-day or low-dose daily steroid therapy, showed highly significant serum hemagglutination-inhibition antibody responses to each influenza virus strain, There was no significant change in mean lymphocyte stimulation index to any influenza virus strain after vaccination in either group. There was no correlation in the patient group between hemagglutination-inhibition antibody titer or response, or lymphocyte stimulation index or response, and the degree of allograft function or dose or duration of immunosuppressive therapy. The vigorous antibody response and the evidence of cellular immunity support the efficacy of influenza vaccination in these patients.
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
October 2009,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
June 2021,
Transplant infectious disease : an official journal of the Transplantation Society,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
November 2006,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
January 2022,
Liver international : official journal of the International Association for the Study of the Liver,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
January 2017,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
May 2019,
Transplantation proceedings,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
April 2006,
Journal of virology,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
June 2000,
Transplantation,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
September 2014,
Transplant international : official journal of the European Society for Organ Transplantation,
W A Briggs, and
R J Rozek, and
S D Migdal, and
J L Shillis, and
R G Brackett, and
F B Brandon, and
S K Mahajan, and
F D McDonald
January 2015,
Human vaccines & immunotherapeutics,
