Biomaterial Database

[Antimitotic activity of methylbenzimidazol-2-yl-carbamate (MBC). I. Light, electron microscopic and physiological studies of germinating conidia of Aspergillus nidulans]. 1980

W Künkel

In the presence of methylbenzimidazol-2-yl carbamate (MBC) swelling of conidia of Aspergillus nidulans was not influenced. The total DNA content per nucleus doubled only once, indicating that the first cell cycle was arrested in the G2-period. Later RNA as well as protein synthesis were inhibited. Nuclear migration into the germ tube and tip growth were delayed. MBC-treatment induced nuclear enlargement and inhibited the first nuclear division in the germinating conidia. A characteristic nuclear invagination developed within which in most cases the enlarged "single NAO" and more less the formed "double NAO" are localized. On the basis of ultrathin sections a model is suggested in which the typical position of "double NAO" in nuclear invagination is demonstrated. The possible relationship between nuclear invagination and NAO-formation, as well as its eventual importance are discussed.

UI	MeSH Term	Description	Entries
D002219	Carbamates	Derivatives of carbamic acid, H2NC(	Carbamate,Aminoformic Acids,Carbamic Acids,Acids, Aminoformic,Acids, Carbamic
D002453	Cell Cycle	The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.	Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D002467	Cell Nucleus	Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D004271	DNA, Fungal	Deoxyribonucleic acid that makes up the genetic material of fungi.	Fungal DNA
D005656	Fungal Proteins	Proteins found in any species of fungus.	Fungal Gene Products,Fungal Gene Proteins,Fungal Peptides,Gene Products, Fungal,Yeast Proteins,Gene Proteins, Fungal,Peptides, Fungal,Proteins, Fungal
D001233	Aspergillus nidulans	A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.	Aspergillus nidulellus,Emericella nidulans
D001562	Benzimidazoles	Compounds with a BENZENE fused to IMIDAZOLES.
D012331	RNA, Fungal	Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.	Fungal RNA