BIOMAT Database Logo BIOMAT Database Logo

HgCl2-induced acute renal failure in the developing rat. 1980

A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna

The present investigation was undertaken to find the differences, if any, in the pattern of nephrotoxic acute renal failure (HgCl2, 4.7 mg/kg body weight SC), in the developing rat and its relationship to the renin angiotensin system. No differences in renal cortical renin content were found between 2, 4, and 8 week olds, but plasma renin concentration was highest at 2 weeks and declined with age. Plasma renin was significantly increased in all groups 6 hr after HgCl2 injection, and the percentage of increase was highest in the 4 week olds. Despite these differences in initial plasma renin and in changes in plasma renin after HgCl2, the pattern of acute renal failure (as assessed by changes in blood urea nitrogen) was similar in the three groups for the first three days. Subsequently, the 4 and 8 week olds exhibited recovery (blood urea nitrogen began to decline), whereas blood urea nitrogen continued to increase to the fifth day in the 2 week olds. The mortality was highest in this group. No simple correlation was observed between basal renal renin, plasma renin, the increase in plasma renin following HgCl2 injection, and the pattern or severity of acute renal failure.

UI MeSH Term Description Entries
D008297 Male Males
D008628 Mercury A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260 Female Females
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000804 Angiotensin II An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. Angiotensin II, Ile(5)-,Angiotensin II, Val(5)-,5-L-Isoleucine Angiotensin II,ANG-(1-8)Octapeptide,Angiotensin II, Isoleucine(5)-,Angiotensin II, Valine(5)-,Angiotensin-(1-8) Octapeptide,Isoleucine(5)-Angiotensin,Isoleucyl(5)-Angiotensin II,Valyl(5)-Angiotensin II,5 L Isoleucine Angiotensin II,Angiotensin II, 5-L-Isoleucine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D058186 Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. Acute Kidney Failure,Acute Kidney Insufficiency,Acute Renal Failure,Acute Renal Injury,Acute Renal Insufficiency,Kidney Failure, Acute,Kidney Insufficiency, Acute,Renal Failure, Acute,Renal Insufficiency, Acute,Acute Kidney Failures,Acute Kidney Injuries,Acute Kidney Insufficiencies,Acute Renal Failures,Acute Renal Injuries,Acute Renal Insufficiencies,Kidney Failures, Acute,Kidney Injuries, Acute,Kidney Injury, Acute,Kidney Insufficiencies, Acute,Renal Failures, Acute,Renal Injuries, Acute,Renal Injury, Acute,Renal Insufficiencies, Acute

Related Publications

A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Metabolic studies of HgCl2-induced acute renal failure in the rat.
August 1981, Experimental and molecular pathology,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Renal hemodynamics in HgCl2-induced acute renal failure.
January 1977, Nephron,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
[HgCl2-induced acute renal failure and its pathophysiology].
January 1998, Nihon eiseigaku zasshi. Japanese journal of hygiene,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
HgCl2-induced acute renal failure studied by split drop micropuncture technique in the rat.
January 1978, Nephron,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
The inhibition of thromboxane synthesis has no influence on HgCl2-induced acute renal failure in the rat.
January 1989, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Hgcl2-induced acute renal failure in the rat. Effect of water diuresis, saline loading, and diuretic drugs.
May 1982, The Journal of laboratory and clinical medicine,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Comparison between mannitol and saline infusion in HgCl2-induced acute renal failure.
January 1984, Nephron,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Glycogen deposition in distal tubular cells during HgCl2 induced acute renal failure.
January 1980, Virchows Archiv. B, Cell pathology including molecular pathology,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Dissociation of glomerular filtration and renal blood flow in HgCl2-induced acute renal failure.
August 1982, Kidney international,
A Bidani, and P C Churchill, and L Fleischmann, and B Becker-McKenna
Effect of beta-receptor antagonists on HgCl2-induced acute renal failure in rats.
January 1982, Renal physiology,
Copied contents to your clipboard!