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Cell-mediated immunity was investigated in spontaneously hypertensive rats (SHR). The thymuses of young SHR rats before developing hypertension had reduced numbers of immature T lymphocytes which were detected by the rosette formation test with guinea-pig erythrocytes in the presence of foetal bovine serum, whereas the thymuses of eight other rat strains tested contained about 60% of rosetting cells. The number of rosetting cells decreased progressively with age. The blastogenic responses to PHA and Con A of the SHR rats' lymphocytes was depressed to less than one-fifth when compared to those of othe rat strains including W/7k rats, the original colony of the SHR rats. Eight-month-old SHR rats showed fewer mitogenic responses than those of 2-month-old SHR rats. Other cell-mediated immune responses, including delayed hypersensitivity, allograft rejections, and a co-operation of T and B lymphocytes to produce humoral antibody formation were depressed significantly when compared to those of other rat strains. Possible mechanisms of immunological depression in the SHR rats in relation to the devleopment of hypertension are discussed.
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 1982,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 1972,
Nihon rinsho. Japanese journal of clinical medicine,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 1970,
Acta medica Iugoslavica,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
July 1999,
Clinical and experimental pharmacology & physiology,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
March 1972,
The Journal of clinical investigation,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 1977,
Zeitschrift fur Versuchstierkunde,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
December 1988,
Experimental hematology,
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
July 1994,
Hypertension (Dallas, Tex. : 1979),
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 1983,
Journal of immunology (Baltimore, Md. : 1950),
N Takeichi, and
K Suzuki, and
T Okayasu, and
H Kobayashi
January 2007,
Behavioural processes,
