-transparent.png){kind=logo}
The hypotensive effect of nifedipine was studied in 9 patients with severe hypertension. After oral administration of 20 mg nifedipine mean arterial pressure (MAP) fell, reaching lowest values about 1 h p.a. The antihypertensive effect lasted 7 h. Treatment with nifedipine alone (80 mg/day) lowered MAP significantly on the first day, but it tended to rise again therealter. Addition of clonidine (450 micrograms/day) or propranolol (120 mg/day) enhanced the hypotensive effect. Furosemide (120 mg/day) was ineffective when added to the above described regimen. Without nifedipine the combine drugs failed to keep MAP down. The decrease of MAP observed when giving this combination of drugs was associated with a significant fall in total peripheral resistance and plasma renin activity, but did not alter cardiac output and blood volume. We concluded that nifedipine together with clonidine or propranolol is very effective in the management of severe hypertension.
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
January 1986,
Clinical pharmacology and therapeutics,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
February 1979,
Annals of clinical research,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
February 1979,
Archives of internal medicine,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
March 1987,
The American journal of medicine,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
August 1981,
British journal of clinical pharmacology,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
August 1987,
Zeitschrift fur Kardiologie,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
August 1980,
Anesthesiology,
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
January 1982,
Cardiologia (Rome, Italy),
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
January 1982,
Cardiologia (Rome, Italy),
Y Imai, and
K Abe, and
Y Otsuka, and
N Irokawa, and
M Yasujima, and
K Saito, and
Y Sakurai, and
S Chiba, and
T Ito, and
M Sato, and
T Haruyama, and
Y Miura, and
K Yoshinaga
January 2016,
BJOG : an international journal of obstetrics and gynaecology,
